Selected region : East
Date: : 18th Nov 2016

Current Studies:

The ENGAGE Study: A Phase 3 Multicentre Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab in Subjects with Early Alzheimer's Disease. Ninewells Hospital & Medical School, Dundee.

 The ENGAGE study is a global clinical research study assessing the efficacy and safety of an investigational medication called Aducanumab, to determine whether it can slow the progression of symptoms in the early stages of Alzheimer's Disease. There are currently no approved treatments that delay memory loss and progression of disability in Alzheimer's. 

If you, or someone you know would like more information about taking part in the ENGAGE Study then click here. By participating in this study it will help research and advance a potential treatment for early Alzheimer's Disease.

The GoDARTS Study: Genetics of Diabetes Audit and Research in Tayside and Scotland. Ninewells Hospital & Medical School, Dundee.

This study wants to understand the role our genes, and other biological markers, play in developing and managing diabetes. By conducting this research it will hopefully provide some answers to some of the following questions surrounding the disease; why do some people develop the disease and others don't; why does medication work for some groups of patients with diabetes and not for others and why do some people develop the complications associated with diabetes and others don't.

The other aim of this study is to look at Metformin, which is one of the most commonly used drugs to treat type 2 diabetes. It can also be used in the treatment of type 1 diabetes in conjunction with insulin therapy. Metformin has been on the market for over 60 years yet its mechanism of action is not fully understood. Some patients respond well to the treatment and encounter very little problems, whilst others find it does not work for them and causes many side-effects.

If you would like to find out more about this study then please click here.

The TARDIS Study: Tracking Antimicrobial Resistance in Respiratory Disease. Ninewells Hospital & Medical School, Dundee.

Antibiotic resistance is a growing problem around the world. Most patients when thet get a chest infection will recover very quickly with antibiotic treatment, but some patients will develop infections with bacteria that becomes resistant to antibiotics. Why some people develop infections with resistance bacteria is not known.

This study is looking at patients with a variety of chest conditions such as asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The researchers will look at the bacteria found in eligible participants by taking a sputum (phlegm) sample and also study their medical records to see whether resistant bacteria are present. By looking through the medical records it can help researchers pinpoint where resistance may have developed through previous antibiotic treatments. The researchers may ask to retain any future sputum samples given so they can study the change in bacteria in the lungs over time.

This study is active and recruiting for eligible participants. To read more about thi study then please click here

The Heart Failure Study: How do Older Heart Failure Patients Manage Their Medication - An Observational Study. Ninewells Hospital & Medical School, Dundee.

Heart Failure (HF) is a common cause of poor health, hospital visits and death, in particular amongst older people. Symptoms and health can be improved with medication but it is found that many people do not take their medications correctly and there is a lack of data as to why this is. This study wants to investigate how accurately patients with heart failure take their medications and explore what stops people from doing so. By understanding what barriers may be stopping HF patients from taking their medication as instructed, this will hopefully provide researchers with new strategies to help these patients. This is an observational study which is looking to recruit patients over 70 years of age in Tayside, with a confirmed diagnosis of HF and currently on medication.

This study is active and recruiting for eligible participants. To find out more about this study then please click here.

The 4P Study: BNP for Personalised Primary Prevention in Diabetes. Ninewells Hospital & Medical School, Dundee.

Diabetes has a huge impact on the function of various organs in the body over the years, even despite good control of the disease. One of the organs that is most affected is the heart, which is reflected in the high cardiovascular death rates amongst diabetic patients. It can be very difficult to pick up on CV problems in patients as a lot of the time there are no noticeable symptoms to suggest there may be a problem. The researchers want to see if there are silent markers in the blood that could indicate any underlying heart problems to improve primary prevention in diabetes.

They will do this by inviting patients with Type 2 diabetes living in Tayside to attend an appointment at Ninewells Hospital to meet with the research team. The results of this study may help predict heart disaese in diabetics who display no symptoms and start them on appropriate treatment early to prevent future CV events.

This study is now active and recruiting for eligible participants. To read more about this study then please click here.

K for Kidneys: Vitamin K Therapy to Improve Vascular Health in Patients with Kidney Disease. Ninewells Hospital & Medical School, University of Dundee.

Reduced kidney function is commonly known as Chronic Kidney Disease (CDK) and is a condition that can affect us as we get older. Poor kidney function does not just have an impact on the kidneys, it also affects the blood vessels which in turn affects the heart and leads to an increased risk of heart disease and strokes. In patients with CKD there is a build-up of calcium within the walls of the blood vessels which makes them stiffer and puts more pressure on the heart. Recent research that has been carried out suggests that there may be a link between Vitamin K and an improvement against this build-up of calcium in the blood vessels. The purpose of this study is to test this theory and see whether Vitamin K does improve vascular health in patients with CKD.

This study is active and recruiting for participants. To find out more about this study then please click here.

 If you wish to hear more about or participate in projects such as those mentioned above please register for SHARE today.

For more information contact us at SHARE@dundee.ac.uk